(Stillness in the Storm Editor) Aging is related to how the body repairs itself. This self-repair ability is tied to gut bacteria due to the fact these microorganisms are instrumental in the production of nutrients along with the mechanism by which we absorb vitamins and release toxins in the digestive tract. The following study looked at the effect of transferring healthy gut bacteria to an unhealthy subject, observing that changes took place that reduced the effects of aging.
Generally speaking, the health of the gut translates into overall health. But in the modern age, the health of the gut has declined considerably, due to toxic food, antibiotics, and heavy metals. Restoring the gut’s health translates into a better emotional function, mental sharpness, resistance to pathogens, faster recovery from injury, and vitality into old age.
Proper detoxification is essential to remove toxins accumulated in modern-day living and diets. For more about this, see our free detox guide and article series.
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(Neuroscience News) An international research team led by Nanyang Technological University, Singapore (NTU Singapore) has found that microorganisms living in the gut may alter the aging process, which could lead to the development of food-based treatment to slow it down.
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by Staff Writer, November 14th, 2019
Summary: Transplanting gut microbiota from older mice to younger germ-free mice increased hippocampal neurogenesis and intestinal growth.
Source: Nanyang Technological University
All living organisms, including human beings, coexist with a myriad of microbial species living in and on them, and research conducted over the last 20 years has established their important role in nutrition, physiology, metabolism and behaviour.
Using mice, the team led by Professor Sven Pettersson from the NTU Lee Kong Chian School of Medicine, transplanted gut microbes from old mice (24 months old) into young, germ-free mice (6 weeks old). After eight weeks, the young mice had increased intestinal growth and production of neurons in the brain, known as neurogenesis.
The team showed that the increased neurogenesis was due to an enrichment of gut microbes that produce a specific short chain fatty acid, called butyrate.
Butyrate is produced through microbial fermentation of dietary fibres in the lower intestinal tract and stimulates production of a pro-longevity hormone called FGF21, which plays an important role in regulating the body’s energy and metabolism. As we age, butyrate production is reduced.
The researchers then showed that giving butyrate on its own to the young germ-free mice had the same adult neurogenesis effects.
The study was published in Science Translational Medicine and was undertaken by researchers from Singapore, UK, and Australia.
“We’ve found that microbes collected from an old mouse have the capacity to support neural growth in a younger mouse,” said Prof Pettersson. “This is a surprising and very interesting observation, especially since we can mimic the neuro-stimulatory effect by using butyrate alone.”
“These results will lead us to explore whether butyrate might support repair and rebuilding in situations like stroke, spinal damage and to attenuate accelerated aging and cognitive decline”.
How gut microbes impact the digestive system
The team also explored the effects of gut microbe transplants from old to young mice on the functions of the digestive system.
With age, the viability of small intestinal cells is reduced, and this is associated with reduced mucus production that make intestinal cells more vulnerable to damage and cell death.
However, the addition of butyrate helps to better regulate the intestinal barrier function and reduce the risk of inflammation.
The team found that mice receiving microbes from the old donor gained increases in length and width of the intestinal villi – the wall of the small intestine. In addition, both the small intestine and colon were longer in the old mice than the young germ-free mice.
The discovery shows that gut microbes can compensate and support an ageing body through positive stimulation.
This points to a new potential method for tackling the negative effects of ageing by imitating the enrichment and activation of butyrate.
“We can conceive of future human studies where we would test the ability of food products with butyrate to support healthy ageing and adult neurogenesis,” said Prof Pettersson.
“In Singapore, with its strong food culture, exploring the use of food to ‘heal’ ourselves, would be an intriguing next step, and the results could be important in Singapore’s quest to support healthy ageing for their silver generation”.
The team showed that the increased neurogenesis was due to an enrichment of gut microbes that produce a specific short chain fatty acid, called butyrate. The image is in the public domain.
Group leader Dr Dario Riccardo Valenzano at the Max Planck Institute for Biology of Ageing in Germany, who was not involved in the study, said the discovery is a milestone in research on microbiome.
“These results are exciting and raise several new open questions for both biology of aging and microbiome research, including whether there is an active acquisition of butyrate producing microbes during mice life and whether extreme aging leads to a loss of this fundamental microbial community, which may be eventually responsible for dysbiosis and age-related dysfunctions,” he added.
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Professor Brian Kennedy, Director of the Centre for Healthy Ageing at the National University of Singapore, who provided an independent view, said, “It is intriguing that the microbiome of an aged animal can promote youthful phenotypes in a young recipient. This suggests that the microbiota with aging have been modified to compensate for the accumulating deficits of the host and leads to the question of whether the microbiome from a young animal would have greater or less effects on a young host. The findings move forward our understanding of the relationship between the microbiome and its host during ageing and set the stage for the development of microbiome-related interventions to promote healthy longevity.”
The study builds on Prof Pettersson’s earlier studies on how transplantation of gut microbes from healthy mice can restore muscle growth and function in germ-free mice with muscle atrophy, which is the loss of skeletal muscle mass.
Source:
Nanyang Technological University
Media Contacts:
Junn Loh – Nanyang Technological University
Image Source:
The image is in the public domain.
Original Research: Open access
“Gut microbiota from old mice confers neurogenic and pro-longevity signatures in young germ-free mice”. Sven Pettersson et al.
Science Translational Medicine doi:10.1126/scitranslmed.aau4760.
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Abstract
Gut microbiota from old mice confers neurogenic and pro-longevity signatures in young germ-free mice
The gut microbiota evolves as the host ages, yet the effects of these microbial changes on host physiology and energy homeostasis are poorly understood. To investigate these potential effects, we transplanted the gut microbiota of old or young mice into young germ-free recipient mice. Both groups showed similar weight gain and skeletal muscle mass, but germ-free mice receiving a gut microbiota transplant from old donor mice unexpectedly showed increased neurogenesis in the hippocampus of the brain and increased intestinal growth. Metagenomic analysis revealed age-sensitive enrichment in butyrate-producing microbes in young germ-free mice transplanted with the gut microbiota of old donor mice. The higher concentration of gut microbiota–derived butyrate in these young transplanted mice was associated with an increase in the pleiotropic and prolongevity hormone fibroblast growth factor 21 (FGF21). An increase in FGF21 correlated with increased AMPK and SIRT-1 activation and reduced mTOR signaling. Young germ-free mice treated with exogenous sodium butyrate recapitulated the prolongevity phenotype observed in young germ-free mice receiving a gut microbiota transplant from old donor mice. These results suggest that gut microbiota transplants from aged hosts conferred beneficial effects in responsive young recipients.
Stillness in the Storm Editor: Why did we post this?
Health is an important human value. Almost everyone, regardless of political affiliation, national origin, or religious association, values being healthy, free of disease and able to pursue their dreams and values. The preceding information discuses health in some capacity, either by alerting the public to poor health choices or suggesting better ways of living for optimum health. With health freedom in hand, which is a primary survival need of all living creatures, the individual can be liberated from fear of personal suffering. This leads to the capacity for holistic thinking, playfulness, and inspired living—activating our capacity to thrive.
– Justin
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Source:
https://neurosciencenews.com/gut-bacteria-aging-15203/
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