(Neuroscience News) DMT, an active compound of the psychedelic Ayahuasca, is naturally occurring in the mammalian brain, researchers have discovered. The study revealed DMT levels increased significantly in the rat visual cortex following cardiac arrest.
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by Staff Writer, June 27th, 2019
In the past few years, thrill-seekers from Hollywood, Silicon Valley and beyond have been travelling to South America to take part in so-called Ayahuasca retreats. Their goal: to partake in a brewed concoction made from a vine plant Banisteriopsis caapi, traditionally used by indigenous people for sacred religious ceremonies. Drinkers of Ayahuasca experience short-term hallucinogenic episodes many describe as life-changing.
The active ingredient responsible for these psychedelic visions is a molecule called dimethyltryptamine (DMT). For the first time, a team led by Michigan Medicine has discovered the widespread presence of naturally-occurring DMT in the mammalian brain. The finding is the first step toward studying DMT– and figuring out its role — within the brains of humans.
“DMT is not just in plants, but also can be detected in mammals,” says Jimo Borjigin, Ph.D., of the Department of Molecular and Integrative Physiology. Her interest in DMT came about accidentally. Before studying the psychedelic, her research focused on melatonin production in the pineal gland.
In the seventeenth century, the philosopher Rene Descartes claimed that the pineal gland, a small pinecone-shaped organ located deep in the center of the brain, was the seat of the soul. Since its discovery, the pineal gland, known by some as the third eye, has been shrouded in mystery. Scientists now know it controls the production of melatonin, playing an important role in modulating circadian rhythms, or the body’s internal clock. However, an online search for notes to include in a course she was teaching opened Borjigin’s eyes to a thriving community still convinced of the pineal gland’s mystical power.
The core idea seems to come from a documentary featuring the work of researcher Rick Strassman, Ph.D. with the University of New Mexico School of Medicine. In the mid-1990s, he conducted an experiment in which human subjects were given DMT by IV injection and interviewed after its effects wore off. In a documentary about the experiment, Strassman claims that he believed the pineal gland makes and secretes DMT.
“I said to myself, ‘wait, I’ve worked on the pineal gland for years and have never heard of this,’” she said. She contacted Strassman, requesting the source of his statement. When Strassman admitted that it was just a hypothesis, Borjigin suggested they work together to test it. “I thought if DMT is an endogenous monoamine, it should be very easy to detect using a fluorescence detector.”
Using a process in which microdialysis tubing is inserted into a rat brain through the pineal gland, the researchers collected a sample that was analyzed for — and confirmed — the presence of DMT. That experiment resulted in a paper published in 2013.
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However, Borjigin was not satisfied. Next, she sought to discover how and where DMT was synthesized. Her graduate student, Jon Dean, lead author of the paper, set up an experiment using a process called in situ hybridization, which uses a labeled complementary strand of DNA to localize a specific RNA sequence in a tissue section.
“With this technique, we found brain neurons with the two enzymes required to make DMT,” says Borjigin. And they were not just in the pineal gland.
“They are also found in other parts of the brain, including the neocortex and hippocampus that are important for higher-order brain functions including learning and memory.”
The results are published in the journal Scientific Reports.
Her team’s work has also revealed that the levels of DMT increase in some rats experiencing cardiac arrest. A paper published in 2018 by researchers in the U.K. purported that DMT simulates the near death experience, wherein people report the sensation of transcending their bodies and entering another realm. Borjigin hopes to probe further to discover the function of naturally occurring levels of DMT in the brain — and what if any role it plays in normal brain functions.
“We don’t know what it’s doing in the brain. All we’re saying is we discovered the neurons that make this chemical in the brain, and they do so at levels similar to other monoamine neurotransmitters.”
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Stillness in the Storm Editor: Why did we post this?
Spiritual renewal or vitalization is a concept that major religions, mystics, and shamans have acknowledged since time immemorial. Modern science has yet to accept the fact that one can gain vitality from a spiritual retreat, mainly because of a prejudice against any metaphysical and phenomenological realities that cannot, as of yet, be measured empirically. The preceding article reveals that, while a thing can’t be measured objectively, that doesn’t mean it doesn’t exist. There is a very real benefit to spiritual work and seasons of reflection that is partially revealed in the above article. With this knowledge in hand, one can begin to develop the mind liberating and life uplifting power of spirit science—the objectively real and measurable effects of a spiritual way of life—the quest to find God and be like him. This information also helps refocus one’s attention on their personal subjective experience with reality, especially with respect to their experience of seeking for and finding the Creator of all things, which is according to some sources, the more truthful and pragmatic definition of religion.
– Justin
Not sure how to make sense of this? Want to learn how to discern like a pro? Read this essential guide to discernment, analysis of claims, and understanding the truth in a world of deception: 4 Key Steps of Discernment – Advanced Truth-Seeking Tools.
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Source:
https://neurosciencenews.com/dmt-psychedelic-brain-14346/
The brain is just an antenna for transduce our mind from “abroad” to this material reality.
DMT is an example of amplification of this antenna…