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Marine Algae As Emerging Therapeutic Alternatives for Depression: A Review.

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(Green Med Info) Marine Algae As Emerging Therapeutic Alternatives for Depression: A Review.

Related Antidepressant Prescriptions for UK Children up 22% in 5 Years

Source – Green Med Info

by Staff Writer, July 31st, 2021

Abstract Source:

Iran J Basic Med Sci. 2021 Aug ;24(8):997-1013. PMID: 34804417

Abstract Author(s):

Kogilavani Subermaniam, Seong Lin Teoh, Yoon-Yen Yow, Yin Quan Tang, Lee Wei Lim, Kah Hui Wong

Article Affiliation:

Kogilavani Subermaniam

Abstract:

Depression is a complex heterogeneous brain disorder characterized by a range of symptoms, resulting in psychomotor and cognitive disabilities and suicidal thoughts. Its prevalence has reached an alarming level affecting millions of people globally. Despite advances in current pharmacological treatments, the heterogenicity of clinical response and incidences of adverse effects have shifted research focus to identification of new natural substances with minimal or no adverse effects as therapeutic alternatives. Marine algae-derived extracts and their constituents are considered potential sources of secondary metabolites with diverse beneficial effects. Marine algae with enormous health benefits are emerging as a natural source for discovering new alternative antidepressants. Its medicinal properties exhibited shielding efficacy against neuroinflammation, oxidative stress, and mitochondrial dysfunction, which are indicated to underlie the pathogenesis of many neurological disorders. Marine algae have been found to ameliorate depressive-like symptoms and behaviors in preclinical and clinical studies by restoring monoaminergic neurotransmission, hypothalamic-pituitary-adrenal axis function, neuroplasticity, and continuous neurogenesis in the dentate gyrus of the hippocampus via modulating brain-derived neurotrophic factors and antineuroinflammatory activity. Although antidepressant effects of marine algae have not been validated in comparison with currently available synthetic antidepressants, they have been reported to have effects on the pathophysiology of depression, thus suggesting their potential as novel antidepressants. In this review, we analyzed the currently available research on the potential benefits of marine algae on depression, including their effects on the pathophysiology of depression, potential clinical relevance of their antidepressant effects in preclinical and clinical studies, and the underlying mechanisms of these effects.

Article Published Date : Jul 31, 2021
Study Type : Review
Additional Links

Substances : Seaweed : CK(176) : AC(61)
Diseases : Depression : CK(6233) : AC(1096)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(8334), Antidepressive Agents : CK(4882) : AC(874), Neuroplasticity enhancement : CK(83) : AC(23)

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Source:

https://www.greenmedinfo.com/article/marine-algae-emerging-therapeutic-alternatives-depression-review

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